Pfizer Corporation Hong Kong Limited 美國輝瑞科研製藥

Indications¹

Feldene Gel contains piroxicam which is a non-steroidal anti-inflammatory agent useful in the treatment of inflammatory conditions. It is used for pain and inflammation such as osteoarthritis, arthrosis, degenerative joint disease, post traumatic or acute musculoskeletal disorders including tendinitis, tenosynovitis, periarthritis, sprains, strains and low back pain.

Clinical Evidence

1. Piroxicam demonstrates a significant increase in efficacy for the treatment of inflammation associated with acute musculoskeletal injuries including sprains and tendinitis².

2. Piroxicam can reduce symptoms (pain on palpation, reduced muscle force and swelling) and can shorten time to complete recovery in acute sports injuries. It is significantly superior in terms of local tenderness at seven days and time to obtain complete relief of symptoms as compared to naproxen³.

3. With similar efficacy, piroxicam demonstrates significantly better toleration than either naproxen or indomethacin².

Safety Profile¹

Very Common and Common Adverse Events:
Mild to moderate local irritation, erythema, rash, pityroid desquamation, pruritus & reactions at application site. Mild but transient skin discoloration.

Drug Interactions

None known.

Dosages¹

For external use only. Apply 1 g to affected site three or four times per day.

Strengths¹

Topical Gel 0.5%

Packing¹

Gel 0.5% x 15g / tube
Gel 0.5% x 25g / tube

Important Safety Information ¹

CONTRAINDICATIONS: Hypersensitivity to the gel or piroxicam in any of its dosage froms. Patients in whom aspirin or other NSAIDs induce symptoms of asthma, rhinitis, angioedema or urticaria.

PRECAUTIONS AND WARNINGS: If local irritation develops, the use of piroxicam topical should be discontinued and appropriate therapy instituted as necessary. Do not apply to eyes, mucosa, open skin lesions or skin conditions affecting the site of application.

COMMON ADVERSE EFFECTS: Mild to moderate local irritation, erythema, rash, pityroid desquamation, pruritus & reactions at application site. Mild but transient skin discoloration.

POST-MARKETING ADVERSE REACTIONS: Contact dermatitis, eczema, and photosensitivity skin reaction.

PREGNANCY AND LACTATION: Pregnancy Category C, D in 3^rd trimester or near delivery. Piroxicam topical is not recommended for use in nursing mothers as the clinical safety has not been established.

Please refer to the full prescribing information for more safety information.

References

1. Feldene™ Gel (Piroxicam) Prescribing Information. Pfizer Corporation Hong Kong Limited: October 2005

2. Heere LP. Piroxicam in acute musculoskeletal disorders and sports injuries. Am J Med 1988:84(Suppl 5A):50—5.

3. Lereim P, Gabor I. Piroxicam and naproxen in acute sports injuries. Am J Med 1988:84(Suppl 5A):45-9

Please review the full product information or package insert before prescribing.

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